When the Port 53 is already in Use, you can check this with this command (ubuntu):

Port 53 is being used at your host machine, that's why you can not bind 53 to host.

To find what is using port 53 you can do: sudo lsof -i -P -n | grep LISTEN

I'm a 99.9% sure that systemd-resolved is what is listening to port 53.

To solve that you need to edit the /etc/systemd/resolved.conf and uncomment DNSStubListener and change it to no, so it looks like this: DNSStubListener=no

After that reboot your system or restart the service with service systemd-resolved restart